Journal Club Discussions
Every other week we will have a Journal Club wherein we discuss a paper in small group formats. There will be a Question sheet that each group will work on collectively - but each person will turn theirs in for a grade.
You are required to PRINT OUT the paper and BRING it to class with you! (bringing it on your laptop or phone does not count!)
you are welcome to print these papers in the Painter Lab (please do 2 pages per sheet to converse paper)
Also, while you are at it - be sure to ask a friend if they need a copy printed too
Journal Club Papers
12th Week: 11/14 none
13th Week: Nov 22nd - In Class exercise (no assigned paper)
Paper:
Link to PDF
14th Week: none
1st Week: none 2nd Week: none
3rd Week: Sept 14th
Paper:
Park, H.; Kim, Y. J.; Hahn, J. S., A novel class of Hsp90 inhibitors isolated by structure-based virtual screening. Bioorganic & Medicinal Chemistry Letters2007,17 (22), 6345-6349.
7th Week: Oct 11th
Paper: Kovac, A.; Konc, J.; Vehar, B.; Bostock, J.; Chopra, I.; Janezic, D.; Gobec, S., Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening. J Med Chem2008,51 (23), 7442-8. KovacDalanineDalanineLigaseVirtualScreenJMedChem2008.pdf
Study Q's: answer these and bring paper copy to class
File Not Found
8th Week: none
9th Week: Oct 25th
Paper: Ruda, G.; Campbell, G.; Alibu, V.; Barrett, M.; Brenk, R.; Gilbert, I., Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem2010,18 (14), 5056-62. RudaTBruceiVirtualDock_6phosphgluconateDehydrogenaseBiorgMedChem2010.pdf
Study Qs:
File Not Found
10th Week: none
11th Week: Nov 8th - Journal Club #5
Paper: A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through
Computational Screening against the Neuraminidase. Jianghong An, Davy C. W. Lee, Anna H.Y. Law, Cindy L.H. Yang, Leo L.M. Poon, Allan S.Y. Lau, and
Steven J.M. Jones J. Med. Chem.2009,52, 2667–2672 AnAvianFluInhibitorsH5N1_ComputationalScreenJMedChem2009.pdf
Study Q's:
Every other week we will have a Journal Club wherein we discuss a paper in small group formats. There will be a Question sheet that each group will work on collectively - but each person will turn theirs in for a grade.
You are required to PRINT OUT the paper and BRING it to class with you! (bringing it on your laptop or phone does not count!)
Journal Club Papers
12th Week: 11/14 none
13th Week: Nov 22nd - In Class exercise (no assigned paper)
Paper:
Link to PDF
14th Week: none
1st Week: none
2nd Week: none
3rd Week: Sept 14th
Paper:
4th Week: none
5th Week: Sept 27th
Paper:
Tomlinson, S.; Malmstrom, R.; Watowich, S., New approaches to structure-based discovery of dengue protease inhibitors. Infect Disord Drug Targets 2009, 9 (3), 327-43.
TomlinsonWatowichDengueVirusInfectiousDisordersDrugTargets2009.pdf
7th Week: Oct 11th
Paper:
Kovac, A.; Konc, J.; Vehar, B.; Bostock, J.; Chopra, I.; Janezic, D.; Gobec, S., Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening. J Med Chem 2008, 51 (23), 7442-8.
KovacDalanineDalanineLigaseVirtualScreenJMedChem2008.pdf
Study Q's: answer these and bring paper copy to class
8th Week: none
9th Week: Oct 25th
Paper:
Ruda, G.; Campbell, G.; Alibu, V.; Barrett, M.; Brenk, R.; Gilbert, I., Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem 2010, 18 (14), 5056-62.
RudaTBruceiVirtualDock_6phosphgluconateDehydrogenaseBiorgMedChem2010.pdf
Study Qs:
10th Week: none
11th Week: Nov 8th - Journal Club #5
Paper: A Novel Small-Molecule Inhibitor of the Avian Influenza H5N1 Virus Determined through
Computational Screening against the Neuraminidase. Jianghong An, Davy C. W. Lee, Anna H.Y. Law, Cindy L.H. Yang, Leo L.M. Poon, Allan S.Y. Lau, and
Steven J.M. Jones J. Med. Chem. 2009, 52, 2667–2672
AnAvianFluInhibitorsH5N1_ComputationalScreenJMedChem2009.pdf
Study Q's: